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:: Volume 26, Issue 1 (12-2021) ::
Andishe 2021, 26(1): 89-96 Back to browse issues page
application of Multifactor dimensionality reduction (MDR) algorithm in detecting the n-locus models related to Behcet’s disease
Anoshiravan Kazemnejad *, Parisa Riyahi, Shayan Mostafaee
Tarbiat Modares University
Abstract:   (658 Views)
 The multifactorial dimension reduction algorithm is considered as a powerful algorithm for identifying high-order interactions in high dimensional structures. In this study, information of 748 patients with Behcetchr('39')s disease who referred to the Rheumatology Research Center, Shariati Hospital, Tehran, and 776 healthy controls was used to identify the interaction effects between ERAP1 gene polymorphisms involved in the occurrence of Behcetchr('39')s disease using the multifactor dimensionality reduction algorithm. Data analysis was performed using MDR 3.0.2 software. The models obtained from the multifactorial dimensional reduction algorithm with balanced accuracy above 0.6 have been determined to increase the risk of Behcetchr('39')s disease. The multi-factor reduction algorithm has high power and speed in calculating the interaction effects of polymorphisms or genetic mutations and identifying important interactions.
Keywords: Multifactor dimensionality reduction algorithm, Behcet’s disease, gene-gen interaction
Full-Text [PDF 572 kb]   (255 Downloads)    
Type of Study: Applicable | Subject: Special
Received: 2021/01/7 | Accepted: 2021/11/22 | Published: 2021/12/1
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Kazemnejad A, Riyahi P, Mostafaee S. application of Multifactor dimensionality reduction (MDR) algorithm in detecting the n-locus models related to Behcet’s disease. Andishe. 2021; 26 (1) :89-96
URL: http://andisheyeamari.irstat.ir/article-1-837-en.html


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Volume 26, Issue 1 (12-2021) Back to browse issues page
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